The normal concentration range of bicarbonate in plasma is 22 to 32 mmol per litre. The average intake of bicarbonate in the diet is negligible and very little is excreted inthe urine under normal conditions; bicarbonate ions formed in the body are excretedin biliary, intestinal, pancreatic and salivary fluids. If bicarbonate is administeredtherapeutically thus increasing the plasma-bicarbonate concentration above thenormal range then compensatory renal mechanisms come to play and bicarbonate isexcreted in the urine. 5.2 Pharmacokinetic properties

Do not take a double dose to make up for a forgotten dose, just carry on with the normal routine. 4. Possible side effects Sodium bicarbonate reduces the absorption of a number of other drugs taken concomitantly. These include ACE inhibitors (captopril, enalapril, and fosinapril), antibacterials and antifungals (azithromycin, cefaclor, cefpodoxime, isoniazid, itraconazole, rifampicin, tetracyclines, ketoconazole and the quinolone group of antibacterials); antivirals (atazanivir, fosamprenavir, tipranavir); antihistamines (fexofenadine); bisphosponates, corticosteroids (deflazacort); digoxin, dipyridamole, antiepileptics (gabapentin and phenytoin), ulcer healing drugs (lansoprazole); levothyroxine, mycophenolate, lipid regulating drugs (rosuvastatin); antipsychotics (sulpiride, phenothiazines), chloroquine, hydrochloroquine, and penicillamine. Antacids should be avoided with nilotinib.Discuss your treatment with your doctor before taking this medicine if any of the above applies to you. Taking other medicines Rate of Perceived Exertion - Hunter AM, De Vito G, Bolger C, Mullany H, Galloway SD The effect of induced alkalosis and submaximal cycling on neuromuscular response during sustained isometric contraction J Sports Sci. (2009 Oct)

Blood Acidity - Price MJ, Singh M Time course of blood bicarbonate and pH three hours after sodium bicarbonate ingestion Int J Sports Physiol Perform. (2008 Jun) have an illness that means you need to control how much salt (sodium) is in your diet, such as high blood pressure or cirrhosis – some antacids contain high levels of sodium, which could make you unwellHow do I take this medicine? Take Sodium Bicarbonate exactly as directed by your doctor. Do not take more or less than instructed by your doctor. Follow your doctor's instructions carefully. Sodium Bicarbonate Capsules are used to treat dyspepsia (heartburn or indigestion). They may also be used to treat acidosis (metabolic or respiratory), a condition wherethe blood is more acidic than it should be. 2. Before you take these capsules i 1 Fo, oral il»-. ..wallow whole with a drink of water. Adults: For indigestion :? " take 2 to 10 capsules as required, or as directed by your doctor.

If you get any side effects, talk to your doctor or pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. The following drugs are reported to be susceptible to inactivation on mixing with sodium bicarbonate solution: adrenaline hydrochloride, benzyl penicillin potassium, carmustine, glycopyrronium bromide, isoprenaline hydrochloride, and suxamethonium chloride.The manufacturers state that sodium bicarbonate should only be used during pregnancy if treatment is clearly necessary. Orally administered sodium bicarbonate is well absorbed and readily crosses the placental barrier. Existing blood pressure dysregulation, such as the physiological respiratory alkalosis associated with pregnancy, may also be increased due to the sodium load. The potential risk is unknown. Lactation Muscle weakness and cramps - caused by a disturbance in your body’s pH(alkalosis). This can happen if you take this medicine for long periods of time or ifyou exceed your recommended dose. They come as a liquid or chewable tablets and can be bought from pharmacies and shops without a prescription. When antacids are used Serum Bicarbonate - Lambert CP, Greenhaff PL, Ball D, Maughan RJ Influence of sodium bicarbonate ingestion on plasma ammonia accumulation during incremental exercise in man Eur J Appl Physiol Occup Physiol. (1993) Like all medicines, Sodium Bicarbonate 500mg Capsules can cause side effects, although not everybody gets them. Stop taking your medicine and tell your doctor immediately if: