Wash your hands thoroughly after applying the cream to avoid getting it in your eyes or transferring it to sensitive areas of skin. The antipyretic effect is reported to be linked to the effect on the prostanoid synthesis due to the fact that the prostanoids are the main signaling mediator of pyresis in the hypothalamic-preoptic region. These ingredients help to ease aches and pains when applied directly to affected muscles and joints.

Medicines and their possible side effects can affect individual people in different ways. Just because a side effect is stated here it does not mean that all people using Radian B ibuprofen gel will experience that or any side effect. Haemodialysis is the treatment of choice for severe poisoning and should be considered in patients with plasma salicylate concentrations >700mg/L (5.1mmol/L), or lower concentrations associated with severe clinical or metabolic features. Patients under ten years or over 70 have increased risk of salicylate toxicity and may require dialysis at an earlier stage.Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

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If you are allergic to salicylates, other non-steroidal anti-inflammatory medicines, or any of the ingredients of this medicine. This cream is unlikely to significantly affect other medicines when applied to unbroken skin. However, the manufacturer recommends that people taking warfarin should get advice from their doctor or pharmacist before using this cream, as if enough salicylate is absorbed through the skin it could potentially enhance the anti-blood-clotting effect of warfarin.