a) Number of SNVs found in each genome, (b) singletons per genome, and (c) the per sample inbreeding coefficient F. Blue bars indicate each individual random bred cat and grey bars indicate each individual breed cat. P-values underneath each x axes were calculated using Wilcoxon rank-sum test and were used to compare breed cats to random bred cats. Dotted lines indicate the mean for each statistic, which is printed above along with standard deviation in braces. (d) Population structure of all unrelated cats (including Bengal breeds) estimated using principal components analysis. Random bred cats are colored light blue. Those that were sampled globally for diversity regions are named according to their sampling location. All other cats are named according to their breed or breed cross. Shendure J, Findlay GM, Snyder MW. Genomic medicine–progress, pitfalls, and promise. Cell. 2019;177(1):45–57. pmid:30901547

New therapeutic strategies are needed for patients with refractory Crohn's disease (CD). We evaluated data from the Crohn's And Treg Cells Study (CATS1) to determine the safety and efficacy of antigen-specific T-regulatory (Treg) cells for treatment of patients with refractory CD. To the left of the figure panels, constraint groups are labeled with pLI ranges shown below in braces. Below the pLI ranges are the number of genes found in each constraint group. SNV values show the total number of SNVs of a particular impact that belong to each constraint group. (a) Observed percentage differences from expected values for per kb SNV density. Light colored rectangles represent the 95% confidence intervals for the expected values. Confidence intervals were calculated using 10,000 permutations (methods). (b) The percentage of SNVs of different impacts and constraint groups across various MAF intervals. (c) Observed percentage differences from expected values for the fraction of SNVs in a singleton state (allele count of 1). Light colored rectangles represent the 95% confidence intervals for the expected values, generated from 10,000 permutations. (d) Pairwise SNV count contrasts between gene constraint groups and SNVs of the same impact. “*” indicates a p-value < 0.05 and “**” indicates a p-value < 0.001. (e) Pairwise singleton count contrasts between gene constraint groups and SNVs of the same impact. Asterisks above odds ratio values indicate the same values as (d). Clarkin CE, Allen S, Kuiper NJ, Wheeler BT, Wheeler-Jones CP, Pitsillides AA. Regulation of UDP-glucose dehydrogenase is sufficient to modulate hyaluronan production and release, control sulfated GAG synthesis, and promote chondrogenesis. J Cell Physiol. 2011;226(3):749–61. Epub 2010/08/19. pmid:20717929. Victoria, a young white cat, is abandoned by her owner in the streets of London in the middle of the night. The alley cats, witnessing this introduce themselves to her as the " Jellicles". Mr. Mistoffelees, Munkustrap, Cassandra and Demeter take Victoria under their wing and show her the world of the Jellicles as they prepare for the Jellicle Ball, an annual ceremony where cats must compete to be chosen to go to the Heaviside Layer and be granted a new life. Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH. Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility. PLoS One. 2012;7(2):e31301. Epub 2012/02/22. pmid:22348067; PubMed Central PMCID: PMC3278431.Lloyd Webber himself was critical of the film, calling it "ridiculous" in an interview with The Sunday Times, saying, "The problem with the film was that Tom Hooper decided that he didn't want anybody involved in it who was involved in the original show." [104] He later revealed in an interview with The Daily Telegraph that "I wrote to the head of Universal and said, 'You've got a car crash on your hands unless you get a grip on this thing', a year before they made (it). I didn't even get a reply." [105] In a 2021 interview with Variety, Lloyd Webber claimed his negative reaction to the film had even directly inspired him to adopt a Havanese dog. [106] Juzwiak, Rich (9 January 2020). "Cats May Have a 10th Life as a Cult Classic". Jezebel. Archived from the original on 15 January 2020 . Retrieved 15 January 2020. Andrew Lloyd Webber warned Universal bosses Cats movie would be 'a car crash' ". Film-News.co.uk. 9 June 2021.

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